Dicerna’s RNA-silencing drug curbs harmful protein in rare liver disease

Drug development for the liver condition alpha-1 antitrypsin deficiency (AATD) has had its ups and downs lately, with Arrowhead Pharmaceuticals and Takeda posting phase 2 success and Vertex reporting two failures in less than a year. Now, Dicerna is revealing promising early results for its RNA-silencing drug for liver disease stemming from the rare, genetic disorder.

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