Nearly two months after GlaxoSmithKline’s U.S. pharma and vaccine head left the Big Pharma in the middle of it making a pandemic shot, Jack Bailey has penned a deal to lead cancer biotech G1 Therapeutics.

As Corvidia CEO, Marc de Garidel saw the heart disease biotech through a $2.1 billion acquisition by Novo Nordisk. Barely two months later, he’s back in the saddle, this time at AZTherapies, a company working on treatments for Alzheimer’s and other neurodegenerative diseases.

After seven years running Merck’s R&D engine, much of which has revolved around cancer blockbuster Keytruda and, now, COVID-19 vaccines, Roger Perlmutter, M.D., Ph.D., is hitting the exit.

Last fall, Myovant’s prostate cancer drug outshone the standard of care at keeping patients’ testosterone levels down, a phase 3 showing that teed up an FDA filing. Now, as the agency ponders the case, the company is unveiling data for patients with metastatic disease—and they’re not so rosy.

When Takeda and Ovid Therapeutics joined forces in 2017, the duo got to work on midstage trials in a pair of rare epilepsies: Dravet syndrome and Lennox-Gastaut syndrome. They’ve since added two more conditions to their pact, and now they’re unveiling data on both.

CStone Pharmaceuticals has seen a $200 million investment from U.S. Big Pharma Pfizer and nabbed a China license for its PD-L1 asset sugemalimab.

A phase 3 trial has linked Alnylam’s lumasiran to a “clinically significant” decline in a substance that drives negative outcomes in children with a rare kidney disease. The top-line readout comes months before the FDA is due to rule on whether to approve the RNAi therapeutic in older patients.

Junshi Biosciences’ PD-1 blocker is already approved in China as a second-line treatment for metastatic melanoma. But the company’s not stopping there—it plans to add other cancer types to the drug’s label, starting with a form of throat cancer.

Preclinical inflammatory disease biotech Ilias Biologics has grabbed a $20.6 million funding round as it eyes a 2021 human test of its leading candidate ILB-202.

When Neil Kumar, Ph.D., started BridgeBio Pharma in 2015, he met a lot of rejection. Investor after investor passed on his idea: picking up rare disease treatments “lying fallow” in academia and developing enough of them simultaneously that they would make money. Now, five years, an IPO and more than 20 programs later, BridgeBio is showing its backers what it’s made of.