A path forward for Merck & Co.’s struggling HIV strategy has opened up, with the FDA releasing a nine-month clinical hold on trials of the Big Pharma’s drug islatravir as long as low doses are used. However, the company has also decided to ditch its plans to explore the drug as a preventive treatment.

Nearly a year into its U.S. rollout, the latest version of Insulet’s diabetes management system is heading across the pond.

While the world is still reeling from the impact of the COVID-19 pandemic, Evotec will be investigating how to treat an infectious disease with a far longer and more deadly history.

Alzheon has released one-year data from a phase 2 study of its Alzheimer’s disease candidate ALZ-801, linking the oral beta amyloid blocker to a reduction in a marker of neuronal stress and brain injury.

A randomized trial of Boston Scientific’s netlike Sentinel device—a miniature strainer designed to catch floating debris in the bloodstream before it can lodge itself within the brain and cause a stroke—failed to meet its primary endpoint as a protective barrier during heart procedures.

ST. LOUIS—Christina Green hoped cataract surgery would clear up her cloudy vision, which had worsened after she took a drug to fight her breast cancer.

Virios Therapeutics’ antiviral fibromyalgia drug candidate IMC-1 has flunked a midphase clinical trial. But, while the prospect failed to improve pain more than placebo in the overall population, Virios is making the case that it was effective after the emergence of the omicron variant of COVID-19.

Alternative lengthening of telomeres cells, or ALT cells, have long presented a challenge for researchers and oncologists alike. Unlike other cancer cells, which use the enzyme telomerase to lengthen their telomeres and grow indefinitely, ALT cells don’t possess telomerase. Instead, these treatment-resistant cells have other means of keeping their telomeres from degrading.

AstraZeneca’s $39 billion acquisition of Alexion last year continues to look like money well spent. The latest good news is that the oral factor D inhibitor danicopan can improve hemoglobin levels when added to the approved drugs Ultomiris or Soliris.

The life science venture capital firm Apple Tree Partners is bringing three of its portfolio companies together under a single banner—and its progeny has raised $100 million to support their newly unified work in delivering pulsed electric field technology to a variety of treatments.