Terns Pharmaceuticals’ prediction that its shelved metabolic dysfunction-associated steatohepatitis (MASH) drug TERN-501 could be effective against obesity in a combination treatment appears to be playing out, at least preclinically.

At the scientific sessions of the American Diabetes Association, multiple studies were presented showing benefits in Type 2 diabetes through a combination of continuous glucose monitoring and automated insulin pumps.

Just last month, Merck KGaA executives were reassuring analysts that the failure of a phase 3 trial of xevinapant was “unlikely.” Now that worst-case scenario has come to pass. The company will now halt both studies on what was once a key brick in the German pharma’s oncology wall.

GLP-1 drugs like Eli Lilly’s Zepbound and Novo Nordisk’s Wegovy work to address obesity—as long as a patient keeps taking them.

Takeda may have pruned back the potential indications for mezagitamab, but the latest raft of phase 2 data suggests the anti-CD38 antibody could still “transform treatment” of primary immune thrombocytopenia (ITP).

Novo Nordisk has shared a closer look at phase 3 results on its hemophilia A candidate Mim8, revealing new data that show how it squares up against Roche’s blockbuster Hemlibra on key measures of efficacy and tolerability.

Researchers at Mass General Brigham found that artificial intelligence software like ChatGPT could help speed up the screening process to find patients eligible for clinical trials—though they cautioned that additional safeguards would be necessary.

After a full data analysis, Altimmune is heralding phase 2 obesity data for pemvidutide as “best-in-class” for spurring weight loss while preserving lean mass.

Two scientists whose work sparked industry excitement about the prospect of using chimeric antigen receptor T cell (CAR-T) therapy for autoimmune disease are the recipients of the Lupus Research Alliance’s annual prize for scientific discoveries.

It’s been nearly three months since the U.S. government announced an outbreak of the bird flu virus on dairy farms. The World Health Organization considers the virus a public health concern because of its potential to cause a pandemic, yet the U.S. has tested only about 45 people across the country.